Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01069 |
TMEM106B Protein, Mouse, Recombinant (hFc)
Transmembrane protein 106B,Tmem |
Mouse | HEK293 Cells |
TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dys... |